In 2004, CellResearch Corporation scientists led by Dr. Toan Thang Phan, our Chief Scientist, discovered Cord Lining Stem Cells in our laboratories. Dr Phan is a Plastic Surgeon by training, and an academic at the National University of Singapore where he holds the position of Associate Professor in Surgery.
Dr. Phan discovered that the Cord Lining produced not one, but two strains of stem cells. These are called Cord Lining Epithelial Cells, and Cord Lining Mesenchymal Cells respectively.
Cord Lining Epithelial Cells come from the upper layers of the cord lining. Their function is to help protect or enclose organs in our body.
Cord Lining Epithelial Cells have been morphed (or differentiated) into
Skin Cells, from which 3-dimensional skin (we call this organotypic skin equivalent) has been made.
Liver Cells, which will be a very useful laboratory drug discovery platform.
Pancreatic Islet Cells, which produce insulin, the hormone lacking in patients with diabetes mellitus.
Cord Lining Mesenchymal Cells come from the deeper layers of the cord lining. Their function is normally to form the connective tissues in our body. Cord Lining Mesenchymal cells can be differentiated into fat cells, cartilage cells, bone cells and nerve cells.
Cord Lining Mesenchymal cells have been morphed (or differentiated) into
Fat Cells, which can be used for surgical reconstruction (e.g. after post traumatic contour defects).
Cartilage Cells, which can be used to repair and resurface joints in patients where the joint cartilage has been damaged (Osteoarthritis or Rheumatoid Arthritis).
Bone Cells, which can be used for repair of bone defects after tumour or trauma.
Nerve Cells, which can be used to replace injured nerves, support the growth of new nerves, or produce nerve substances that are lacking (e.g. dopamine in patients with Parkinson’s Disease).